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An Overview of Medications for Hypertension

November 14, 2001

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Page 1THIAZIDE AND RELATED DIURETICS
Page 2LOOP DIURETICS
POTASSIUM-SPARING DIURETICS
Page 3ANGIOTENSIN CONVERTING ENZYME INHIBITORS (ACE INHIBITORS)
ANGIOTENSIN II RECEPTOR (TYPE AT1) ANTAGONIST
Page 4OTHER AGENTS
Page 5BETA-ADRENORECEPTOR BLOCKERS
Page 6DIRECT-ACTING VASODILATORS
Page 7CALCIUM CHANNEL BLOCKERS
Sources of Information

THIAZIDE AND RELATED DIURETICS

  1. How these agents work
    • cause volume of blood to drop and
    • cause blood vessels to open
  2. adverse effects
    • loss of potassium...may lead to muscle cramping
    • increases in blood uric acid...may contribute to gout
    • increases in blood sugar...diabetics need to be careful
  3. specific agents
    • bendroflumethiazide (Naturetin®)
    • benzthiazide (Exna®)
    • chlorothiazide (Diuril®, Diurigen®)
    • HYDROCHLOROTHIAZIDE (Hydrodiuril®, Esidrex®, et al.)
    • hydroflumethiazide (Saluron®, Diucardin®)
    • methyclothiazide (Enduron®, Aquatensen®)
    • polythiazide (Renese®)
    • trichlormethiazide (Naqua®, Metahydrin®, Diurese®)

    HYDROCHLOROTHIAZIDE is probably the single most important antihypertensive diuretic, used alone or in combination drug therapy.

  4. thiazide-related diuretics
    • chlorthalidone (Hygroton®, Thalitone®)
    • quinethazone (Hydromox®)
    • metolazone (Zaroxolyn®, Mykrox®)
    • indapamide (Lozol®)

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